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Key takeaways GLP-1 agonists are a class of drugs that were originally designed to treat type 2 diabetes, but their use has expanded to include weight loss, heart and kidney disease risk reduction, and management of obstructive sleep apnea

GLP-1RAs and osteoclasts The greater degree of bone degradation observed in mice lacking GLP-1R indicates that GLP-1R signaling suppresses osteoclast differentiation and bone resorption