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Discussion We have used single-cell force spectroscopy (SCFS) for proving the existence of a long-hypothesized TNF-induced inside-out-signaling mechanism that reinforces integrin-mediated Jurkat cell adhesion

2 Mechanisms of OS-induced nerve damage In the context of DN, OS contributes to oxidase activation, mitochondrial dysfunction, apoptosis, inflammation, and endoplasmic reticulum (ER) stress, which are critical in the pathogenesis of nerve injury (Figure 1)

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