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1 Introduction Obesity, diagnosed as a body mass index (BMI) 30 kg/m 2 , is a progressive, chronic disease that has grown to pandemic prevalence over the past decades ( Figure 1 ) ( Figure 1 While traditionally recognized primarily as a disease of the elderly, T2D is currently one of the most frequently diagnosed preventable chronic diseases in middle age, as well as children and adolescents ( Lifestyle modifications, such as balanced nutrition, calorie restriction and physical exercise, remain the cornerstone of any weight loss intervention
Amino acid substitutions : Specific amino acids within the peptide backbone are reported to have been substituted or modified to improve resistance to enzymatic degradation, including by dipeptidyl peptidase-4 (DPP-4), thereby improving metabolic stability
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