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H 2 also displays an anti-inflammatory effect in I/R cerebral injury or allergic rhinitis animal model by upregulating regulatory T cells (Tregs), which exerts the immunosuppressive function and inhibits the expression of NF-B (Li et al., 2016

Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels

In 2015, another double-blind RCT reported significant improvements in pain associated with aphthous ulcers with a B12 ointment compared with a B12-free ointment

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