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It has been projected that up to 57% of the climatically suitable habitat for rooibos could be lost due to climate change (Ltter et al

This includes, for example, using mitochondrial-targeted nanoprodrugs to inhibit both aerobic glycolysis and oxidative phosphorylation, thereby reversing cisplatin resistance [237], or delivering glycolysis inhibitors to deprive drug-resistant cells of their energy source [238]

As chronic PE induces tissue changes that go beyond skeletal muscle tissue (e.g., increase in mitochondria in adipose tissue), it is plausible that changes such as improvement in mitochondrial metabolism (improves their structure and function) in the epidermis also could occur in response to physical training practice (see Figure 6)