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Serpina3n limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase

Microscopically, differentiated (simplex) PeIN is characterized by a thickened epithelium, usually associated with elongated and anastomosing rete ridges, subtle abnormal maturation (enlarged keratinocytes with abundant eosinophilic cytoplasm), whorling and keratin pearl formation (usually in deep rete ridges), prominent intercellular bridges (spongiosis and sometimes acantholysis), and atypical basal cells with hyperchromatic nuclei (116)

This signaling inhibition dampens T cell effector functions, including cytotoxicity and the production and secretion of IFN-, TNF-, and IL-2