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Add GIP receptor activation, as Tirzepatide does, and you layer in improved insulin sensitivity, enhanced fat metabolism, and what appears to be reduced GI side effects compared to GLP-1-only approaches

Additionally, weight loss with GLP-1 RAs is accompanied by reductions in lean mass, with skeletal muscle accounting for approximately 15%40% of total weight loss (Pandey et al., 2024

Because these medications act on the digestive system, its not surprising that many of the side effects are related to digestion

Stronger appetite suppression makes it easy to undereat protein, which leads to muscle loss alongside fat loss