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Oral L-carnitine has lower bioavailability than injectable forms (approximately 15-25% absorption versus near-complete absorption for injectables), which is why oral doses need to be higher

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For comparison, the median plasma lycopene in an observational study of plasma lycopene concentrations in 111 participants in a trial involving -carotene was 0.59 mol/L [267]

During IVT, modified bases are commonly introduced by substituting native pyrimidines with analogs such as fluoropyrimidines (F-Py), O-methyl (OMe) groups, or amino groups at the 2 position of deoxyribose