[13] Conversely, significant energy deficit and rapid weight loss can temporarily suppress reproductive hormones a phenomenon recognised in functional hypothalamic amenorrhoea potentially reducing sexual drive in some individuals (see NICE CKS: Amenorrhoea)
Where the Science Still Has Gaps Several questions remain unresolved: optimal dosing for therapeutic applications long-term systemic safety standardized clinical protocols large randomized human trials These gaps highlight the difference between promising experimental science and established clinical practice
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