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To further confirm the observed Y1234/1235 phosphorylation, we performed in-cell imaging of Met phosphorylation, using the most active dimeric macrocycles, and monitoring by immunofluorescence microscopy of EHMES-1 cells (Supplementary Fig

By binding G-actin, thymosin beta-4 helps regulate the available pool of monomeric actin that cells draw on for cytoskeletal remodeling, which is part of how cells migrate during wound repair

It's about respecting the science and understanding that the smallest details often have the largest impact

Every aspect of the process from dose selection and escalation strategy to participant monitoring and safety review is designed to support informed decision-making while maintaining participant protection as the central priority