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Both the application of antibiotic stewardship principles and timely considerations through the regulatory pathways are needed to release the next generation of antibiotics that are suitable for the fight against superbugs

16 , 17 The M1 phenotype is associated with the release of cytokines and mediators that amplify inflammation and promote neurotoxicity, whereas the M2 phenotype suppresses inflammation and fosters tissue repair

Furthermore, LRRK2 mutationsparticularly G2019Sare linked to disrupted mitochondrial dynamics, altered kinase activity, and aberrant autophagy (Franco et al., 2021