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The three most common causes: (1) peptide degradation due to improper storage (temperature excursions above 8C after reconstitution), (2) complete avoidance of UV exposure (MT2 requires UV to trigger melanosome transfer), or (3) dosing below the melanogenic threshold (fewer than 0.25mg per injection or inconsistent dosing frequency)

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Wegovy is FDA-approved for weight loss and management in adults with obesity or overweight who have at least one weight-related health condition (e.g., high blood pressure, diabetes), as well as adults and children ages 12 and older with obesity