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Each enzyme family is characterized by a distinct 3D structure, amino acid sequence, and with regard to the metal-binding cofactor(s) used to support its structural stability and catalytic activity (Case 2017): either manganese (MnSOD), nickel (NiSOD), or both copper and zinc (Miller 2012)

Abbreviations ATP: Adenosinetriphosphate CADD: Computer aided drug design CDI: Carbonyldiimidazole DIPEA: N, N-diisopropylethylamine DMF: Dimethylformamide GDP: Guanosinediphosphate GN: Guanosine nucleotide GppNHp: Guanosine-5-[(,)-imido]triphosphate GST: Glutathione-S-transferase GTP: Guanosinetriphosphate KRAS: Kirsten rat sarcoma MD: Molecular dynamics MS: Mass spectrometry RBD: Ras binding domain SOS: Son of sevenless SWIIP: Switch-II-pocket References Scheffzek, K

In addition, there is no guarantee it will translate to positive fund performance

Second-generation line probe assay for hepatitis C virus genotyping