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Alcohol is already known to cause GI distress, such as upset stomach, diarrhea, and acid reflux, so you may feel even worse when its combined with the medication (which can also cause those things)

When added to insulin in the setting of inadequately controlled type 2 diabetes, oral semaglutide was superior to placebo at improving glycemic control and reducing body weight over 26 weeks, with significant differences also seen at 52 weeks, and with no increase in the risk of hypoglycemia, Bernard Zinman , MD, a senior investigator at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, and colleagues wrote

These boast enhanced bioavailability and visible skin-balancing properties