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Furthermore, this copper-binding capability is what distinguishes GHK-Cu from non-copper tripeptides and underpins the bulk of its research interest

In the Wnt pathway, the key step of the Wnt pathway is the binding of the Wnt protein to the Frizzled receptor, and the nuclear redox protein (NRX) blocks Disheveled (DVL) and plays a negative regulatory role in the Wnt pathway (Yu et al., 2021)

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Although very rare, serious side effects have been reported including eye abnormalities, pancreatitis, hepatitis, ulcerative colitis, Crohns disease, anaphylactic shock, Stevens-Johnson syndrome, and suicide attempts